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Bone changes in postmenopausal Spanish women

H Rico1, E R Hernández, M Revilla

  • 1Department of Medicine, Príncipe de Asturias Hospital, Alcalá de Henares University, Madrid, Spain.

Calcified Tissue International
|February 1, 1993
PubMed
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Postmenopausal women experience significant bone loss, particularly in the axial skeleton within the first five years after menopause. Bone mass reduction rates vary across body areas over time.

Area of Science:

  • Bone biology and osteoporosis research.
  • Gerontology and menopausal health studies.

Background:

  • Menopause is associated with accelerated bone loss, increasing osteoporosis risk.
  • Understanding the temporal and regional patterns of bone mass reduction is crucial for targeted interventions.

Purpose of the Study:

  • To quantify bone mass reduction in different body areas over time since menopause.
  • To investigate whether bone loss patterns are uniform across the skeleton postmenopause.

Main Methods:

  • Bone mineral density measurements of total body, axial, and peripheral skeleton.
  • Analysis of 258 postmenopausal women categorized into 5-year groups based on years since menopause.

Main Results:

  • Significant reduction in trunk bone mass (-12.3%) and total body bone density (TBBD) (-5.8%) observed within 1-5 years postmenopause.

Related Experiment Videos

  • Accelerated peripheral bone loss (-9% arms, -7.3% legs) noted in the 5-10 years postmenopause group.
  • Substantial axial bone loss (-28.9%) and TBBD reduction (-20.3%) observed after 25 years postmenopause.

    • Conclusions:

    • Bone mass reduction rates differ significantly between axial and peripheral sites.
    • Early postmenopausal years show marked axial bone loss, emphasizing the need for timely monitoring.
    • Extrapolation of bone loss from one skeletal region to another is not advisable.