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Biodegradable starch microspheres for cerebral arterial embolization

O Laccourreye¹, A Laurent, M Polivka

¹Laboratory of Clinical Research in Oncology and Otolaryngology, Hopital Laënnec, University Paris V, France.

Investigative Radiology

|February 1, 1993

Summary

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Biodegradable starch microspheres used for brain embolization showed dose-dependent effects and caused permanent ischemic damage, despite their rapid biodegradability.

Area of Science:

Biomedical Engineering
Neuroscience
Materials Science

Background:

Intracerebral and cervical arterial embolization are crucial for treating head and neck tumors and vascular malformations.
Various embolic materials have been employed, necessitating evaluation of new agents.

Purpose of the Study:

To assess the clinical and histopathologic outcomes of biodegradable starch microspheres for cerebral arterial embolization.
To investigate the safety and efficacy of Spherex microspheres in a rodent model.

Main Methods:

A novel embolization technique preserving carotid artery integrity and flow was developed.
Biodegradable starch microspheres (Spherex) were administered via the external carotid artery in 20 Sprague-Dawley rats.

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Main Results:

Cerebral embolization consequences were directly related to the quantity of microspheres used.
Spherex microspheres exhibited distinct behavior in the brain compared to other degradable agents.

Conclusions:

Biodegradable starch microspheres can induce permanent ischemic brain damage, irrespective of their degradation rate.
The amount of embolic material is a critical factor influencing outcomes in cerebral embolization.