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Related Experiment Videos

Spatial integration among cells forming the cranial peripheral nervous system

D M Noden1

  • 1Department of Anatomy, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401.

Journal of Neurobiology
|February 1, 1993
PubMed
Summary

Neural crest cells are crucial for spatial organization in the developing vertebrate head. Their migration and interactions with other cells guide the positional specification of craniofacial tissues.

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Area of Science:

  • Developmental Biology
  • Neuroscience
  • Genetics

Background:

  • Neural crest cells connect axial and peripheral regions in vertebrate head development.
  • The role of neural crest cells in spatial organization and positional specification remains debated, with ongoing discussion about segmental arrangements versus underlying spatial programming.
  • Mechanisms for positional specification of sensory neurons from neural crest and placodes are not fully understood.

Purpose of the Study:

  • To review the spatial organization of cells and tissues developing near sensory neurons.
  • To examine how these cells acquire site-specific properties and integrate functionally.
  • To elucidate the role of neural crest cells in coordinating cell migration and tissue interactions.

Main Methods:

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  • Review of existing literature on neural crest cell fates, Hox gene expression, and cell migration patterns.
  • Analysis of spatial relationships between migrating neural crest cells and branchial arch myoblasts.
  • Examination of hierarchical interactions among mesenchymal cell populations during development.

    • Main Results:

    • Neural crest cells play a dominant role in the spatial organization of craniofacial tissues.
    • Coordinated cell migration, such as between neural crest cells and branchial arch myoblasts, is key to functional integration.
    • Constant rostro-caudal relationships are maintained during cell migration from hindbrain regions to branchial arches.

    Conclusions:

    • Neural crest cells are central to establishing spatial organization and positional specification in the developing head.
    • Interactions among mesenchymal cells are hierarchical, with neural crest cells integrating environmental cues.
    • Understanding neural crest cell behavior is essential for comprehending craniofacial development and sensory neuron specification.