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Long-term cyclosporin A therapy for severe idiopathic membranous nephropathy

G Rostoker1, D Belghiti, A Ben Maadi

  • 1Department of Nephrology, Hôpital Henri-Mondor, Créteil, France.

Nephron
|January 1, 1993
PubMed

Insights

Cyclosporin A (CyA) treatment showed good results in 73% of patients with idiopathic membranous nephropathy (MN). This immunosuppressive therapy may be effective for MN, warranting further controlled trials.

Area of Science:

  • Nephrology
  • Immunology

Background:

  • Idiopathic membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults.
  • Patients with predictors of poor outcome require effective treatment strategies.

Purpose of the Study:

  • To evaluate the efficacy and safety of a long-term cyclosporin A (CyA) regimen in patients with idiopathic MN and poor prognostic factors.

Main Methods:

  • A cohort of 15 patients with nephrotic MN received CyA (4-5 mg/kg/day) for a median of 15 months.
  • Treatment response was assessed by proteinuria levels; partial remission (< 2 g/day), complete remission (< 0.2 g/day).

Main Results:

  • 11 of 15 patients (73%) achieved partial or complete remission.
  • Four patients (27%) did not respond and discontinued CyA.
  • Three of 9 patients experienced relapses upon CyA withdrawal, which remained responsive to CyA.
  • Side effects were mild.

Conclusions:

  • Long-term cyclosporin A therapy demonstrates potential efficacy in treating idiopathic membranous nephropathy.
  • CyA may be a viable treatment option for MN patients with poor prognostic indicators.
  • Further controlled trials are recommended to confirm these findings.

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