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Deep penetrating nevus

D A Mehregan1, A H Mehregan

  • 1Pinkus Dermatopathology Laboratory, Monroe, Mich.

Archives of Dermatology
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Deep penetrating nevus is a benign pigmented lesion that can mimic melanoma. Recognizing its unique histologic features is crucial for accurate diagnosis and avoiding unnecessary treatment.

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Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Deep penetrating nevus (DPN) is a melanocytic nevus variant.
  • Histologic features can resemble malignant melanoma, causing diagnostic challenges.

Purpose of the Study:

  • To review clinical and histologic features of DPN.
  • To aid in differentiating DPN from melanoma.

Main Methods:

  • Retrospective review of 14 DPN cases.
  • Analysis of clinical presentation and histopathology.

Main Results:

  • DPN commonly affects acral skin in young adults.
  • Histology shows wedge-shaped lesions extending into deep dermis/subcutaneous fat.
  • Melanocytes are arranged in nests/fascicles around adnexa; low-grade atypia and rare mitoses are noted.

Conclusions:

  • DPN is a benign nevus with deep dermal and subcutaneous extension.
  • Distinguishing DPN from malignant melanoma is essential.