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Methazolamide-induced skin eruptions
S B Gandham1, G L Spaeth, M Di Leonardo
1Glaucoma Service, Wills Eye Hospital, Philadelphia, Pa.
Abstract:
To our knowledge, this is the first histopathologic report of skin eruptions due to oral methazolamide. From the four cases studied, we conclude that there are at least two histopathologic types: one is characterized by perivascular lymphocytic infiltrate with a vacuolar alteration at the dermoepidermal junction, the other by perivascular eosinophils, lymphocytes, and scattered mast cells. There also seem to be at least two patterns of skin eruptions: one maculopapular and the other urticarial. The type of skin eruption and the histopathologic type appear to be related.
Insights
This study details the first histopathologic findings of skin reactions from oral methazolamide. Two distinct histopathologic types and two eruption patterns were identified and appear related.
Area of Science:
- Dermatology
- Histopathology
- Pharmacology
Background:
- Oral methazolamide is a medication used to treat glaucoma and epilepsy.
- Adverse skin reactions to medications can significantly impact patient quality of life.
- Histopathologic characterization of drug-induced skin eruptions is crucial for diagnosis and management.