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Mixed haplotypes and autoimmunity
N R Nygard1, D M McCarthy, J Schiffenbauer
1Beirne Carter Center, Health Sciences Center, University of Virginia, Charlottesville 22908.
Immunology Today
|February 1, 1993
Abstract:
Why do (NZB x NZW)F1 mice develop an autoimmune lupus-like syndrome? The second exons of the class II genes of NZB and NZW are identical to their counterparts of H-2d and H-2u haplotypes. Several lines of evidence suggest that this allows the production of a mixed haplotype molecule, I-E alpha dE beta z, and that this molecule plays a key role in the development of autoimmunity.