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111In-labeled Mn-metalloporphyrin for tumor imaging
S Nakajima1, H Yamauchi, I Sakata
1Division of Surgical Operation, Asahikawa Medical College, Japan.
Nuclear Medicine and Biology
|February 1, 1993
Abstract:
We synthesized and developed a new tumor imaging agent, 111In-labeled metalloporphyrin (111In-ATN-10) which consists of a carrier (ATN-10) of the tumor imaging possessing both a non-radioactive manganese complex in the porphyrin ring and a bifunctional chelating group (DTPA) attached to its side chain. The images of the three kinds of tumors were delineated more clearly by 111In-ATN-10 than 67Ga-citrate. Moreover, there was no photosensitivity in ATN-10. 111In-ATN-10 is studied as a new tumor positive scintigraphic agent instead of 67Ga-citrate.