Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contingent negative variation: methods and potential interest in headache

J Schoenen1, M Timsit-Berthier

  • 1University Department of Neurology, CHR de la Citadelle, University of Liège, Belgium.

Cephalalgia : an International Journal of Headache
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monoclonal antibodies blocking CGRP transmission: An update on their added value in migraine prevention.

Revue neurologique·2020
Same author

One-year prevalence of migraine using a validated extended French version of the ID Migraine™: A Belgian population-based study.

Revue neurologique·2015
Same author

Analysis and clinical correlates of 20 Hz photic driving on routine EEG in migraine.

Acta neurologica Belgica·2014
Same author

Brain functional connectivity and morphology changes in medication-overuse headache: Clue for dependence-related processes?

Cephalalgia : an international journal of headache·2014
Same author

Potentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks.

European journal of neurology·2013
Same author

[Migraine: from genetics to environment].

Revue medicale de Liege·2012
Same journal

Iatrogenic harm in paediatric and adolescent populations of patients with migraine: A systematic review with meta-analysis.

Cephalalgia : an international journal of headache·2026
Same journal

Rimegepant for migraine prevention in clinical practice: A multicenter study including patients with prior anti-CGRP monoclonal antibody failure (GEMA project).

Cephalalgia : an international journal of headache·2026
Same journal

Cerebrovascular risk with calcitonin gene-related peptide monoclonal antibodies versus onabotulinumtoxinA in patients with migraine: A real-world pharmacoepidemiologic study in the National Institutes of Health All of Us Research Program.

Cephalalgia : an international journal of headache·2026
Same journal

Burning mouth syndrome and oral dysaesthetic/perceptual symptoms: Toward clinically actionable boundaries.

Cephalalgia : an international journal of headache·2026
Same journal

Effectiveness and clinical predictors of rimegepant for acute vertigo in vestibular migraine: A real-world cohort study.

Cephalalgia : an international journal of headache·2026
Same journal

Efficacy of digital therapeutic sinCephalea for personalised nutrition versus control for migraine prevention: A 12-week open-label randomised clinical trial.

Cephalalgia : an international journal of headache·2026
See all related articles

Contingent negative variation (CNV) brain potentials are abnormal in migraine patients without aura, showing increased amplitude and lack of habituation. These neurophysiological findings may indicate central catecholaminergic pathway hyperreactivity.

Area of Science:

  • Neuroscience
  • Clinical Neurophysiology

Background:

  • Migraine is a common neurological disorder.
  • Event-related potentials like Contingent Negative Variation (CNV) are increasingly studied in migraine pathophysiology.
  • Previous research suggests CNV abnormalities in migraine.

Purpose of the Study:

  • To describe the methodology of CNV.
  • To investigate CNV characteristics in migraine patients with and without aura.
  • To explore the potential of CNV as a diagnostic tool for migraine.

Main Methods:

  • Description of Contingent Negative Variation (CNV) methodology, noting its requirement for specialized equipment and expertise.
  • Comparison of CNV amplitude and habituation patterns between migraine patients (with and without aura) and controls, assessed between attacks.

Related Experiment Videos

  • Evaluation of CNV sensitivity and specificity as a diagnostic marker for migraine.

    • Main Results:

    • Migraine patients without aura exhibited increased average CNV amplitude and a lack of habituation between attacks.
    • Migraine patients with aura did not show these specific CNV abnormalities.
    • CNV amplitude normalized in migraine patients after treatment with beta-blockers.
    • CNV demonstrated low sensitivity but high specificity as a diagnostic tool.

    Conclusions:

    • CNV abnormalities, specifically increased amplitude and impaired habituation, are characteristic of migraine without aura between attacks.
    • These findings suggest a potential role for hyperreactivity in central catecholaminergic pathways in migraine pathophysiology.
    • CNV, despite low sensitivity, offers high specificity for diagnosing migraine.