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Quantitative sensory threshold testing in patients with multiple sclerosis

M P Merchut1, G Gruener

  • 1Department of Neurology, Loyola University Medical Center, Maywood, Illinois 60153.

Electromyography and Clinical Neurophysiology
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

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Quantitative sensory testing revealed sensory abnormalities in 75% of multiple sclerosis patients, particularly at the great toe. This noninvasive method shows promise for correlating with clinical and somatosensory evoked potential findings.

Area of Science:

  • Neurology
  • Neuroscience
  • Sensory Physiology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease affecting the central nervous system.
  • Early detection of sensory deficits in MS is crucial for disease management and monitoring progression.
  • Quantitative sensory testing (QST) offers a potential noninvasive method to assess sensory function.

Purpose of the Study:

  • To evaluate the utility of quantitative sensory threshold testing in patients with definite multiple sclerosis.
  • To compare QST findings with clinical assessments and somatosensory evoked potential (SSEP) results.

Main Methods:

  • Cutaneous thresholds for vibratory and thermal stimuli were measured at the index finger and great toe in 12 MS patients.
  • Somatosensory evoked potential (SSEP) studies were performed on 10 of these patients.

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Main Results:

  • 75% of MS patients exhibited abnormalities in vibratory or thermal sensory thresholds.
  • Abnormalities were more prevalent in the great toe (48% vibratory, 17% thermal).
  • SSEP testing showed high rates of abnormalities: 80% for median and 90% for tibial studies.

Conclusions:

  • Quantitative sensory threshold testing is a simple, noninvasive technique that appears to correlate with clinical and SSEP findings in MS.
  • Further research is needed to establish the sensitivity and diagnostic value of QST in MS.
  • QST may serve as a valuable tool for detecting and monitoring sensory pathway involvement in multiple sclerosis.