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Related Experiment Videos

Cibenzoline transforms random re-entry into ordered re-entry in the atria

J Brugada1, S Gürsoy, P Brugada

  • 1Cardiovascular Center, OLV Hospital, Aalst, Belgium.

European Heart Journal
|February 1, 1993
PubMed
Summary

Cibenzoline, a class I drug, converts atrial fibrillation to atrial tachycardia by slowing conduction. This antiarrhythmic effect transforms chaotic electrical activity into organized re-entry pathways in the atria.

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[Not Available].

Arquivos brasileiros de cardiologia·2016

Area of Science:

  • Cardiology
  • Electrophysiology
  • Pharmacology

Background:

  • Atrial fibrillation (AF) is a complex arrhythmia.
  • Class I antiarrhythmic drugs are known to affect cardiac electrophysiology.
  • Understanding the substrate of AF is crucial for developing effective treatments.

Purpose of the Study:

  • To test if class I drugs modify the electrophysiological substrate of atrial fibrillation.
  • To investigate the effects of cibenzoline on atrial activation patterns in patients with AF.

Main Methods:

  • Electrophysiological study in 20 patients with spontaneous or induced AF.
  • High-resolution epicardial mapping (248 channels) before and after cibenzoline administration.
  • Intra-operative mapping in one patient undergoing a 'corridor' operation.

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Main Results:

  • Cibenzoline converted AF to regular monomorphic atrial tachycardia in 18/20 patients.
  • Mean atrial cycle length significantly prolonged from 147 ms to 302 ms (P < 0.001).
  • Sinus rhythm was restored in 8/18 patients; mapping showed fusion of wavelets into ordered re-entry.

Conclusions:

  • Cibenzoline transforms random re-entry into ordered re-entry in the atria.
  • This effect is likely due to the drug's depression of atrial conduction.
  • Cibenzoline demonstrates potential as an antiarrhythmic agent for AF management.