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[Transient acantholytic dermatosis (Grover)]

H H Wolff

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |February 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Transient acantholytic dermatosis presents with trunk papules in men over 40, often resolving quickly. Histology shows epidermal changes, with its distinctiveness needing further study.

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    Area of Science:

    • Dermatology
    • Histopathology
    • Electron Microscopy

    Background:

    • Transient acantholytic dermatosis (TAD) is a skin condition.
    • Previous descriptions of TAD exist.

    Purpose of the Study:

    • To describe the clinical, histopathological, and electron microscopical features of transient acantholytic dermatosis.
    • To evaluate the commonality and distinctiveness of TAD.

    Main Methods:

    • Clinical observation of patient lesions.
    • Histopathological examination of skin biopsies.
    • Electron microscopy of affected epidermal cells.

    Main Results:

    • Clinically, TAD presents as papules (smooth or keratotic) or papulovesicles, primarily on the trunk of males over 40.

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  • Lesions typically resolve within weeks, though some cases may persist.
  • Histological findings include focal epidermal changes resembling Darier's disease, Hailey-Hailey disease, pemphigus (vulgaris or foliaceus), or a spongiotic-acantholytic pattern, often in combination.

    • Conclusions:

    • Transient acantholytic dermatosis exhibits characteristic clinical and histological features.
    • The condition appears to be relatively common.
    • Further research is needed to confirm the distinctiveness of transient acantholytic dermatosis.