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Metformin and liver glycogen synthase activity in obese Zucker rats
R Huupponen1, K Pyykkö, M Koulu
1Department of Clinical Pharmacology, University of Turku, Finland.
Research Communications in Chemical Pathology and Pharmacology
|February 1, 1993
Abstract:
The effect of chronic treatment with metformin (320 mg/kg/day) on plasma glucose and insulin as well as liver glycogen synthase activity and hepatic glycogen content was studied in obese hyperinsulinemic Zucker rats. Metformin significantly reduced both plasma glucose (by 10%) and insulin levels (by 39%) at fasting but had no effect on hepatic glycogen content or on the basal activity of liver glycogen synthase.