[Anti-edematous effects of cinnarizine]

Experiments carried out with male mice (28-32 g) of CFLP strain have shown that cinnarizine significantly inhibits the extents of ear oedema induced by croton oil or capsaicin. In rats of Wistar strain, oedema was induced in the hind paw by subplantar injection of carrageenin, and simultaneously by the application of croton oil to the inner surface on the ear. Preliminary cinnarizine treatment inhibited the development of both types of oedema, to statistically significant extent.