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Radioimmunoguided radical prostatectomy and lymphadenectomy
R A Badalament1, J K Burgers, L R Petty
1Department of Surgery, Arthur G. James Cancer Hospital and Research Institute, Columbus, Ohio.
Cancer
|April 1, 1993
Summary
Radioimmunoguided surgery (RIGS) is feasible for detecting prostate cancer during surgery. This technique successfully identified tumors in all 10 patients, including occult cancers, supporting further research.
Area of Science:
- Oncology
- Surgical Oncology
- Nuclear Medicine
Background:
- Prostate cancer diagnosis and surgical treatment present challenges for complete tumor removal.
- Intraoperative detection methods are crucial for improving surgical outcomes.
Purpose of the Study:
- To evaluate the feasibility of radioimmunoguided surgery (RIGS) for intraoperative detection of prostate cancer.
- To assess the efficacy of a B72.3 monoclonal antibody-based RIGS system in identifying prostate tumors.
Main Methods:
- A pre-Phase I clinical study involved 10 patients undergoing radical prostatectomy.
- Patients received iodine 125-radiolabeled B72.3 monoclonal antibody targeting TAG-72.
- Intraoperative detection was performed using a gamma-detecting probe for RIGS.
Main Results:
- The RIGS system successfully localized prostate tumors in all 10 patients.
- Clinically occult, bilateral intraprostatic tumors were identified in three patients.
- RIGS detected tumor in lymph nodes of three patients, with two confirmed histologically.
Conclusions:
- The study supports the feasibility of the RIGS technique for prostate cancer surgery.
- Further clinical studies are warranted to validate and expand the use of RIGS.