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Related Experiment Videos

Cholestrol and cholesteryl ester content in normal and pathologic scale

C Schmidt, N S Penneys, V A Ziboh

    The Journal of Investigative Dermatology
    |April 1, 1977
    PubMed
    Summary

    Callus is not a suitable control for skin studies. Psoriatic and ichthyotic skin show altered cholesterol levels, with more free cholesterol and less esterified cholesterol compared to normal skin.

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    Area of Science:

    • Biochemistry
    • Dermatology
    • Lipid Metabolism

    Background:

    • Stratum corneum lipid composition is crucial for skin barrier function.
    • Understanding sterol content in various skin conditions is important for diagnosis and treatment.
    • Previous studies may have used unsuitable control tissues for stratum corneum research.

    Purpose of the Study:

    • To accurately measure cholesteryl ester and cholesterol in stratum corneum from different skin types.
    • To compare lipid profiles in normal skin, callus, psoriatic lesions, and lamellar ichthyotic lesions.
    • To determine the suitability of callus as a control tissue for stratum corneum sterol studies.

    Main Methods:

    • Utilized a sensitive new assay to quantify cholesteryl ester and cholesterol.

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  • Analyzed samples from stratum corneum of callus, normal skin, psoriatic lesions (plantar and nonplantar), and lamellar ichthyotic lesions (plantar and nonplantar).

    • Main Results:

    • Normal stratum corneum had significantly higher cholesteryl ester content than callus.
    • Callus is unsuitable as a control for stratum corneum sterol studies.
    • Psoriatic and lamellar ichthyotic scales showed increased free cholesterol and decreased esterified cholesterol compared to controls.

    Conclusions:

    • Callus is not an appropriate control for biochemical studies of stratum corneum sterol content.
    • Altered free and esterified cholesterol levels are characteristic of psoriatic and lamellar ichthyotic lesions.
    • Findings highlight differences in lipid metabolism in diseased skin states.