Related Experiment Video
Updated: Aug 17, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
Published on: July 16, 2016
Betacellulin: a mitogen from pancreatic beta cell tumors
Y Shing1, G Christofori, D Hanahan
1Department of Surgery, Children's Hospital, Boston, MA.
Abstract:
Betacellulin, a member of the epidermal growth factor family, has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors. Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain of betacellulin has 50 percent sequence similarity with that of rat transforming growth factor alpha. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Related Concept Videos
Cell Specific Gene Expression
Insulin Secretory Vesicles

