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Natural history of blue sclerae in osteogenesis imperfecta
D Sillence1, B Butler, M Latham
1Medical Genetics and Dysmorphology Unit, Children's Hospital, Camperdown, New South Wales, Australia.
American Journal of Medical Genetics
|January 15, 1993
Abstract:
Scleral hue is an important sign which distinguishes 2 broad groupings of patients, those with and those without blue sclerae with nonlethal osteogenesis imperfecta (OI). Individuals with OI type I have distinctly blue sclerae which remain intensely blue throughout life. In OI type III and OI type IV the sclerae may also be blue at birth and during infancy, but the intensity fades with time such that these individuals have sclerae of normal hue by adolescence and adult life.