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Differential protein binding of ceftizoxime in cord versus maternal serum
S J Fortunato1, S I Welt, J T Stewart
1Department of Obstetrics and Gynecology, Tulane University, School of Medicine, New Orleans, LA 70112.
American Journal of Obstetrics and Gynecology
|March 1, 1993
Abstract:
Ceftizoxime concentrations are higher in cord blood and amniotic fluid than in maternal blood. More avid binding to fetal serum proteins is a suggested mechanism. We measured ceftizoxime protein binding in fetal and maternal blood and documented significantly less protein binding to fetal proteins (21.9% vs 57.8%).