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Syntheses and insulin-like activity of phosphorylated galactose derivatives
H N Caro1, M Martín-Lomas, M Bernabé
1Grupo de Carbohidratos, Instituto de Química Orgánica General, C.S.I.C., Madrid, Spain.
Carbohydrate Research
|February 24, 1993
Abstract:
The syntheses of the poly-phosphorylated galactosides 6, 8, 10, 13, 16, and 20, isolated as sodium salts, have been performed. The non-phosphorylated disaccharide 17 and trisaccharide 21 have been prepared via glycosylation of the 2-(trimethylsilyl)ethyl galactosides 3 and 2, respectively, and subsequent complete deprotection. Preliminary insulin-like activity of the phosphorylated derivatives is reported.