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The difference in miscarriage rates between menotropin-induced and natural cycle pregnancies is not surveillance
M X Ransom1, M Bohrer, M B Blotner
1Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick.
Objective:
To assess the reportedly higher miscarriage rate during menotropin-induced cycle pregnancies as compared with natural cycle.
Design:
Prospective cohort groups were selected, and pregnancies were identified 16 to 18 days after insemination and followed through to outcome.
Patients:
Three hundred twelve patients were studied: 251 women receiving human menopausal gonadotropin and 61 requiring donor insemination without medication.
Results:
A significant difference between the spontaneous abortion rate of gonadotropin-treated women (28.5%) and women conceiving during natural cycles (11.7%) was demonstrated.
Conclusion:
The opinion that higher miscarriage rates in menotropin-treated women are related to a surveillance bias compared with natural cycle conceptions should be reconsidered.