Related Experiment Videos
Synthesis of substrate analogues for trypanothione reductase
A F el-Waer1, T Benson, K T Douglas
1Department of Pharmacy, University of Manchester, UK.
International Journal of Peptide and Protein Research
|February 1, 1993
Abstract:
The synthesis and chemical characterisation of a range of substrate analogues for trypanothione reductase are described, with the spermidine portion of trypanothione replaced by the 3-dimethylaminopropylamide moiety. Using 1-hydroxybenzotriazole/N-hydroxysuccinimide coupling, products were obtained which had a range of replacements of the gamma-glutamyl groups of the enzyme substrate. The materials were characterised by FPLC, 1H/13C NMR spectroscopy and FAB mass spectroscopy.