High-performance liquid chromatography of ergometrine and preliminary pharmacokinetics in plasma of men

¹Department of Gynaecology, University Hospital Nijmegen Sint Radboud, Netherlands.

|March 5, 1993

Abstract:

An isocratic high-performance liquid chromatographic (HPLC) method with fluorescence detection has been developed for the measurement of ergometrine in human plasma. The quantitation limit in plasma was 75 pg/ml. An example of the plasma concentration-time curves obtained after both oral and intravenous administration of ergometrine in one volunteer is shown. This HPLC method makes it possible to describe the pharmacokinetic parameters of oral ergometrine.

Related Concept Videos

Articles linked to this work by shared authors, journal, and citation graph.

HPLC analysis and pharmacokinetics of the enantiomers of R,S-oxazepam and R,S-temazepam with their corresponding glucuronide conjugates in urine and plasma of man.

Acta neuropsychiatrica·2016

Pharmacokinetics of anthracyclines in dogs: evidence for structure-related body distribution and reduction to their hydroxy metabolites.

Pharmaceutical research·2013

Decision-making performance is related to levels of anxiety and differential recruitment of frontostriatal areas in male rats.

Neuroscience·2011

Comparison of the effects and disposition kinetics of lidocaine and (+/-)prilocaine in patients undergoing axillary brachial plexus block during day case surgery.

Clinical drug investigation·2008

Sex-related differences in the pharmacokinetics of isosorbide-5-mononitrate (60 mg) after repeated oral administration of two different original prolonged release formulations.

International journal of clinical pharmacology and therapeutics·2004

[Hydrops fetalis as an indication for a systematic investigation into the presence of lysosomal storage diseases].

Nederlands tijdschrift voor geneeskunde·2004

See all related articles

Related Experiment Videos

High-performance liquid chromatography of ergometrine and preliminary pharmacokinetics in plasma of men

Related Concept Videos

HPLC analysis and pharmacokinetics of the enantiomers of R,S-oxazepam and R,S-temazepam with their corresponding glucuronide conjugates in urine and plasma of man.

Pharmacokinetics of anthracyclines in dogs: evidence for structure-related body distribution and reduction to their hydroxy metabolites.

Decision-making performance is related to levels of anxiety and differential recruitment of frontostriatal areas in male rats.

Comparison of the effects and disposition kinetics of lidocaine and (+/-)prilocaine in patients undergoing axillary brachial plexus block during day case surgery.

Sex-related differences in the pharmacokinetics of isosorbide-5-mononitrate (60 mg) after repeated oral administration of two different original prolonged release formulations.

[Hydrops fetalis as an indication for a systematic investigation into the presence of lysosomal storage diseases].

Rapid synthesis of isoprenoid diphosphates and their isolation in one step using either thin layer or flash chromatography.

[Electrophoresis of radionuclides on cellogel].

Frontal affinity chromatography: theory for its application to studies on specific interactions of biomolecules.

Determination of the calcium antagonist SIM6080 in plasma by high-resolution gas chromatography.

Processing of envelope polypeptides of herpes simplex virus type 1. Demonstration of variation in different cell lines by high-performance liquid chromatography and radioimmunoprecipitation.

Measurement of GABA in rat brain microdialysates using o-phthaldialdehyde-sulphite derivatization and high-performance liquid chromatography with electrochemical detection.

Related Experiment Videos

High-performance liquid chromatography of ergometrine and preliminary pharmacokinetics in plasma of men

Abstract:

Related Concept Videos

Related Articles