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Exogenous hormones and human cancer
1Epidemiology Division, National Cancer Center Research Institute, Tokyo.
Japanese Journal of Clinical Oncology
|February 1, 1993
Summary
Exogenous hormones, including oral contraceptives and growth factors, are increasingly linked to human cancers. This review examines the carcinogenic risks associated with various hormone therapies and medical treatments.
Area of Science:
- Endocrinology
- Oncology
- Pharmacology
Background:
- Endogenous hormones play a known role in hormone-related cancers.
- Increasing medical use of exogenous hormones raises concerns about iatrogenic carcinogenesis.
- Long-term data clarify risks from oral contraceptives for liver and endometrial cancers.
Purpose of the Study:
- To review the carcinogenic risks associated with exogenous hormone use.
- To evaluate the potential role of various hormone therapies in human neoplasm development.
Main Methods:
- Literature review of case reports and long-term studies.
- Analysis of risks from commonly used exogenous hormones and growth factors.
Main Results:
- Oral contraceptives are associated with liver and endometrial adenoma and carcinoma.
- Other exogenous hormones and growth factors may also contribute to human cancer risk.
Conclusions:
- Exogenous hormone consumption in medical treatments presents a growing concern for human carcinogenesis.
- Further research is needed to fully elucidate the oncogenic potential of various exogenous hormones and growth factors.