Related Experiment Videos
Two color flow cytometric analysis of lymphocytes in HTLV-I carrier children
T Sato1, M Yanagisawa, H Muchi
1Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
Abstract:
Phenotypic changes in lymphocytes from healthy children with antibody for human T lymphotrophic virus type I (HTLV-I) were studied using two color flow cytometry. The subjects were high school students within a small district of Kyushu, Japan. In the carrier group, a subset of lymphocytes which expressed CD8+CD57+ was significantly lower in percentage (P < 0.01) and in number (P < 0.05). There was no significant difference between carriers and non-carriers in the percentage and number of CD4+Leu8+ cells or CD4+HLA-DR+ cells. The IgG levels were slightly higher in carriers than in non-carriers (P < 0.05). These findings suggest that HTLV-I-infected cells may affect the immune system in healthy carrier children.