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Flunitrazepam in terminal care

O R Smales1, E A Smales, H G Sanders

  • 1Department of Paediatrics, Memorial Hospital, Hastings, New Zealand.

Journal of Paediatrics and Child Health
|February 1, 1993
PubMed
Summary
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Flunitrazepam effectively manages agitation and confusion in terminally ill patients. This long-acting benzodiazepine provides good symptom control without excessive sedation in adults and children.

Area of Science:

  • Pharmacology
  • Palliative Care
  • Pediatrics

Background:

  • Flunitrazepam is a long-acting benzodiazepine with sedative, anxiolytic, muscle relaxant, and anticonvulsant properties.
  • It is recognized for its efficacy in managing various symptoms in adult palliative care.

Observation:

  • This study describes the use of flunitrazepam in children during their terminal illness.
  • The drug was administered via subcutaneous infusion, often in combination with other medications.

Findings:

  • Flunitrazepam demonstrated effectiveness in controlling terminal agitation, confusion, restlessness, dystonia, and seizures.
  • Good symptom control was achieved in pediatric patients over the 24 hours preceding death.
  • Crucially, this symptom management occurred without inducing excessive sedation.

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Implications:

  • Flunitrazepam offers a viable option for symptom management in pediatric palliative care.
  • Its use in subcutaneous infusions provides a flexible administration route for terminally ill children.
  • Further research may explore optimal dosing and combination therapies for enhanced pediatric end-of-life care.