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[Oro-esophageal candidiasis resistant to fluconazole in patients with AIDS]
1Facultad de Medicina y Odontología, Universidad de Santiago de Compostela, La Coruña.
Background:
Fluconazole-resistant Candida albicans has been seldom reported in the literature. in this study, two clinical cases of oro-esophageal candidosis resistant to this antifungal drug are described.
Method:
Infection was confirmed by isolation of yeasts (culture of mouth swabs, oesophagoscopy and histology of biopsy specimens). In vitro antifungal susceptibility tests were performed with standard methods (NCCLS).
Results:
Clinical and microbiological fluconazole-resistant Candida albicans was isolated.
Conclusions:
Causes of development of resistances are commented, and the role of immunodeficiency and the possibility of a Candida strain selection is discussed.