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Updated: Oct 23, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell
1Specialty Medical Services Department, Saudi Aramco Medical Services Organization, Dhahran, Saudi Arabia.
Abstract:
Three children with homozygous sickle cell disease, 22 months and 8 and 10 years of age, had clinical and hematologic manifestations of aplastic and splenic sequestration crisis simultaneously. They had an acute drop in hemoglobin level (16, 20, and 45 gm/L), reticulocytopenia (0.1%, 0.6%, and 0.3%), and sudden splenic enlargement. Evidence of recent parvovirus infection was demonstrated.
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