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Cardiovascular abnormalities in children with fragile X syndrome
L S Crabbe1, A S Bensky, L Hornstein
1Department of Pediatrics, Cincinnati Center for Developmental Disorders, OH 45229.
Pediatrics
|April 1, 1993
Summary
Cardiac abnormalities like mitral valve prolapse are not common in young children with fragile X syndrome. These issues appear to develop later in childhood and adolescence, requiring careful monitoring.
Area of Science:
- Cardiology
- Genetics
- Pediatrics
Background:
- Fragile X syndrome is associated with increased prevalence of mitral valve prolapse and aortic root dilation.
- The occurrence of these cardiac abnormalities in young children with fragile X syndrome is not well-established.
Purpose of the Study:
- To determine the prevalence of cardiac abnormalities in young children with fragile X syndrome.
- To understand the developmental timeline of cardiac issues in fragile X syndrome.
Main Methods:
- Studied sixteen boys and one girl aged 13 years or younger with fragile X syndrome.
- Assessed for typical examination findings of mitral valve prolapse.
Main Results:
- Only one child (6%) exhibited findings suggestive of mitral valve prolapse.
- This child's echocardiogram, however, was normal, indicating no definitive structural abnormality at this age.
Conclusions:
- Cardiac abnormalities in fragile X syndrome likely manifest in late childhood and adolescence, not early childhood.
- Long-term monitoring of children with fragile X syndrome is crucial for documenting the onset of cardiac conditions.