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Do nasal ciliary changes reflect bronchial changes? An ultrastructural study

F Verra1, J Fleury-Feith, M Boucherat

  • 1Service de Pneumologie, Hôpital Intercommunale de Créteil, France.

The American Review of Respiratory Disease
|April 1, 1993
PubMed
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Nasal samples accurately reflect bronchial ciliary changes in patients with ciliary dyskinesia, simplifying diagnosis. This study confirms nasal biopsies are sufficient for detecting axonemal ultrastructural abnormalities, reducing patient discomfort.

Area of Science:

  • Respiratory Medicine
  • Cell Biology
  • Genetics

Background:

  • Ciliary dyskinesia causes recurrent respiratory infections due to abnormal cilia.
  • Diagnosis relies on detecting axonemal ultrastructural abnormalities (AUA) in respiratory samples.
  • Nasal samples are typically used, but their correlation with bronchial samples is unconfirmed.

Purpose of the Study:

  • To determine if nasal ciliary samples accurately reflect bronchial ciliary changes in patients with ciliary dyskinesia.
  • To assess the necessity of bronchial sampling for diagnosing ciliary dyskinesia.

Main Methods:

  • Investigated 12 patients with chronic sputum production, divided into inherited disorder and non-inherited disorder groups.
  • Obtained nasal and bronchial mucosal samples via brushing or biopsy.

Related Experiment Videos

  • Analyzed samples using transmission electron microscopy to identify axonemal ultrastructural abnormalities.

    • Main Results:

    • Significant correlation found between nasal and bronchial samples for total AUA (r'=1, p<0.01) and outer dynein arm defects (r'=0.96, p<0.05).
    • In patients with inherited disorders (Group 1), mean AUA was 65.2%.
    • In patients without inherited disorders (Group 2), mean AUA was 9.6%.

    Conclusions:

    • Nasal samples are a reliable indicator of bronchial ciliary abnormalities in ciliary dyskinesia.
    • Nasal sampling is sufficient for diagnosing axonemal ultrastructural abnormalities, eliminating the need for bronchial biopsies.
    • This simplifies the diagnostic process for ciliary dyskinesia, improving patient comfort and potentially reducing healthcare costs.