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Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes
1Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Immunology Today
|March 1, 1993
Abstract:
Leukocyte recruitment from the blood circulation into tissue is essential for effective immune responses, and is, consequently, carefully regulated. In this article Yoshiya Tanaka and co-workers describe a model in which proteoglycans on the luminal surface of endothelium capture pro-adhesive cytokines. These cytokines provide the adhesion-inducing signal to particular leukocyte subsets which initiates their transmigration.