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The human gene for the zona pellucida glycoprotein ZP3 and a second polymorphic locus are located on chromosome 7
M van Duin1, J E Polman, R F Suikerbuijk
1Department of Immunology, Organon International, Oss, The Netherlands.
Cytogenetics and Cell Genetics
|January 1, 1993
Abstract:
Southern blot analysis of genomic DNA and gene-cloning experiments have recently shown that the human ZP3 gene is not a single-copy gene. The human genome harbors sequences encoding a protein of 424 amino acids and, in addition, a polymorphic locus with the potential to give rise to a probably nonfunctional polypeptide of 372 residues. In this report it is shown, by screening of a panel of human x hamster hybrid cell lines, that both the ZP3 and ZP3P loci are located on human chromosome 7.