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Updated: Aug 18, 2026

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
Published on: February 24, 2014
Risk factors for the development of secondary malignancies after marrow transplantation
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Abstract:
Bone marrow transplantation is associated with several risk factors that may predispose patients to the development of a new malignancy post-transplant. Several types of malignancies, including lymphoproliferative disorders, new leukemias, and solid tumors have been observed. Risk factors include treatment of acute graft-versus-host disease with monoclonal or polyclonal antibodies, total body irradiation, HLA nonidentity, and T-cell depletion. It is currently unknown whether longer follow-up will show a further increase or decline in the incidence of secondary tumors.
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