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Treatment of therapy-related acute myelogenous leukemia and myelodysplastic syndromes
1Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Hematology/Oncology Clinics of North America
|April 1, 1993
Abstract:
The number of cases of therapy-related acute myelogenous leukemia and myelodysplastic syndromes has risen with the advances of successful combination chemotherapy. Unfortunately, the therapy-related diseases are difficult to treat. Aggressive induction chemotherapy can induce a complete remission, but the remission duration is short. Differentiating agents, hormonal agents, and growth factors have all been disappointing. Allogeneic bone marrow transplantation remains the only curative approach.