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Published on: July 15, 2012
Regulation of serotonin-induced calcium uptake in Spisula oocytes by tricyclic antidepressants
1Center for Biomedical Research, Population Council, New York, NY 10021.
Abstract:
The effect of tricyclic antidepressants on 5-hydroxytryptamine (serotonin or 5-HT)-induced maturation and Ca2+ uptake in Spisula oocytes was determined. The drugs at a concentration of 20 microM completely blocked germinal vesicle breakdown and 45Ca2+ uptake by Spisula oocytes. The order of effectiveness of the antidepressants were imipramine > desipramine > clomipramine. The present findings suggest that the action of tricyclic antidepressants is to regulate Ca2+ uptake into 5-HT-responsive cells.
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