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Botulinum toxin treatment for spasmodic dysphonia

T Kobayashi1, S Niimi, M Kumada

  • 1Department of Otolaryngology, Japan Railway Tokyo General Hospital.

Acta Oto-Laryngologica. Supplementum
|January 1, 1993
PubMed
Summary

Botulinum toxin injections effectively treat adductor spasmodic dysphonia, improving voice for about 3 months. Limiting injections to one vocal fold and using low doses minimizes temporary side effects like hoarseness.

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Area of Science:

  • Otolaryngology
  • Neurology
  • Speech Pathology

Background:

  • Adductor type spasmodic dysphonia (AdSD) is a chronic neurological voice disorder.
  • Botulinum toxin (BT) injections are a recognized treatment for AdSD.
  • Optimal injection techniques and dosage require further clarification.

Purpose of the Study:

  • To evaluate the efficacy and safety of botulinum toxin injections for adductor spasmodic dysphonia.
  • To describe methods for minimizing complications associated with BT injections in the larynx.

Main Methods:

  • Retrospective review of patients with AdSD treated with unilateral vocal fold BT injections.
  • Objective and subjective assessments of phonation pre- and post-injection.
  • Analysis of complication rates based on injection technique and dosage.

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Main Results:

  • Patients experienced significant objective and/or subjective improvements in voice quality.
  • The therapeutic effect of botulinum toxin injections typically lasted for approximately 3 months.
  • Temporary hoarseness or aphonia, a common complication, was reduced by unilateral injections and doses under 5 units.

Conclusions:

  • Unilateral botulinum toxin injections are an effective treatment for adductor spasmodic dysphonia.
  • Careful technique and dosage management can minimize immediate complications, enhancing treatment safety.