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Salivary total protein and experimental Coriolis sickness
M Igarashi1, M F Reschke, C Henley
1University Research Center, Nihon University, Tokyo, Japan.
Acta Oto-Laryngologica. Supplementum
|January 1, 1993
Summary
Baseline salivary protein levels may predict motion sickness severity. This study found changes in salivary protein concentration correlate with Coriolis sickness symptoms, offering a potential objective measure for susceptibility.
Area of Science:
- Physiology
- Neuroscience
- Biochemistry
Background:
- Symptomatic reporting is the standard for quantifying motion sickness severity.
- Objective biomarkers for motion sickness susceptibility are needed.
Purpose of the Study:
- To investigate the relationship between dynamic changes in salivary protein concentration and Coriolis sickness severity.
- To determine if baseline salivary protein levels can predict Coriolis sickness susceptibility.
Main Methods:
- Healthy adults underwent a modified Coriolis Sickness Susceptibility Index (CSSI) test.
- Salivary samples were collected at baseline and various time points during stimulation.
- Total protein concentration was measured in salivary samples.
Main Results:
- Salivary total protein concentration generally increased within the first 30 minutes of stimulation.
- A statistically significant difference was observed between pre-stimulation and 30-minute samples.
- Baseline salivary protein levels showed an inverse correlation with the time to reach nausea, suggesting predictive value.
Conclusions:
- Dynamic changes in salivary protein concentration are associated with Coriolis sickness.
- Baseline salivary total protein levels may serve as a predictor for Coriolis sickness and other motion sickness forms.
- Salivary protein analysis offers a potential objective method for assessing motion sickness susceptibility.