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Changes in auditory evoked responses during intravenous lidocaine
1Department of Otolaryngology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Acta Oto-Laryngologica. Supplementum
|January 1, 1993
Summary
Intravenous lidocaine temporarily reduced tinnitus loudness and altered auditory evoked responses. This suggests lidocaine acts on both the inner ear and brain-stem to alleviate tinnitus symptoms.
Area of Science:
- Neuroscience
- Otolaryngology
- Pharmacology
Background:
- Tinnitus is a complex auditory disorder affecting millions.
- Understanding the neurophysiological basis of tinnitus is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the effects of intravenous lidocaine on auditory evoked responses in patients with tinnitus.
- To determine the potential sites of action for lidocaine in alleviating tinnitus.
Main Methods:
- Auditory evoked responses, including electrocochleography (ECochG) and auditory brain-stem response (ABR), were recorded in 21 tinnitus patients.
- A dosage of 1 mg/kg intravenous lidocaine was administered.
- Tinnitus loudness was assessed using a 0-11 score during recordings.
Main Results:
- A temporary reduction in tinnitus loudness was observed.
- Auditory evoked responses showed momentary changes, including prolonged AP latency on ECochG and prolonged inter-peak latencies (IPL) of wave I-III and wave III-V on ABR.
- These electrophysiological changes correlated with tinnitus reduction.
Conclusions:
- Lidocaine administration impacts auditory pathways involved in tinnitus perception.
- The findings suggest that lidocaine's therapeutic effect on tinnitus involves actions at both the inner ear and the brain-stem.
- Further research into lidocaine's mechanism could inform novel tinnitus therapies.