Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone cement and antibiotics

E Ger, D Dall, T Miles

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |February 26, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Current Management Practices for Endometrial Cancer (EC) in the UK: A National Healthcare Professional Survey (KNOW-EC).

    Clinical oncology (Royal College of Radiologists (Great Britain))·2024
    Same author

    Current and future genomic applications for surgeons.

    Annals of the Royal College of Surgeons of England·2024
    Same author

    Lagrangian coherent structure assisted path planning for transoceanic autonomous underwater vehicle missions.

    Scientific reports·2018
    Same author

    The future for follow-up of gynaecological cancer in Europe. Summary of available data and overview of ongoing trials.

    European journal of obstetrics, gynecology, and reproductive biology·2017
    Same author

    Fat is a realist's issue.

    BJOG : an international journal of obstetrics and gynaecology·2016
    Same author

    Delays in treating endometrial cancer in the South West of England.

    British journal of cancer·2011
    Same journal

    SAMA Health Summit Abstracts.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    On behalf of the South African Medical Association (SAMA), The Scientific Committee of the SAMA Health Summit, is pleased to pesent this abstract issue, showcasing the posters and oral presentations delivered at the Summit, which was held from 22-24 May 2026.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Proceedings of the 2<sup>nd</sup> Data Driven Surgery Conference (DDSC 2025).

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Clinical practice guidelines for the management of fever and neutropenia in South African children and adolescents with cancer.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    The changing fortunes of the District Health System in SA (1994 - 2020): A retrospective review.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Thomas Micheal Guntram Ignaz Rehle (1951 - 2025).

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    See all related articles

    Adding powdered antibiotics to polymethylmethacrylate bone cement minimally impacts mechanical strength (<10% loss). This preserves cement integrity while conferring potent antibacterial properties for potential clinical applications.

    Area of Science:

    • Biomaterials Science
    • Orthopedic Surgery
    • Infectious Disease

    Background:

    • Bone cement, such as polymethylmethacrylate (PMMA), is widely used in orthopedic procedures.
    • Preventing surgical site infections is a critical challenge in orthopedic surgery.
    • Incorporating antibiotics into bone cement is a strategy to deliver localized antimicrobial agents.

    Purpose of the Study:

    • To investigate the effects of incorporating various antibiotics into PMMA bone cement.
    • To evaluate the mechanical properties and antibacterial efficacy of antibiotic-loaded PMMA.
    • To assess the potential clinical utility of antibiotic-modified PMMA in orthopedic applications.

    Main Methods:

    • Antibiotics were mixed with powdered PMMA at a concentration of 1 g antibiotic/40 g cement.

    Related Experiment Videos

  • Mechanical testing, including compressive strength and elastic modulus, was performed using an Instron Universal Testing Machine.
  • In vitro studies assessed the antibacterial activity of the antibiotic-loaded PMMA against various bacteria.

    • Main Results:

    • Powdered antibiotics resulted in a minimal loss (<10%) of compressive strength and elastic modulus.
    • Liquid antibiotics led to a greater reduction in compressive strength but decreased porosity.
    • All tested antibiotics, except chloramphenicol, exhibited potent in vitro antibacterial activity.

    Conclusions:

    • Incorporating powdered antibiotics into PMMA bone cement maintains significant mechanical integrity.
    • Antibiotic-loaded PMMA demonstrates effective in vitro antibacterial activity, offering a promising approach for infection prevention.
    • Further in vivo studies are warranted to support widespread clinical adoption.