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Adverse effects on sperm movement characteristics in women with minimal and mild endometriosis
P Curtis1, P Lindsay, A E Jackson
1Department of Obstetrics and Gynaecology, Royal Free Hospital, London, UK.
Objective:
To test the effect of peritoneal fluid from infertile women with minimal or mild endometriosis on sperm movement characteristics in comparison with fertile and infertile women with no endometriosis.
Design:
A prospective observer-blind trial.
Setting:
Academic infertility department.
Subjects:
57 women undergoing diagnostic laparoscopy or laparoscopic sterilisation.
Main Outcome Measures:
Changes in sperm movement characteristics in semen samples provided during routine infertility investigation or from sperm donors. Computer assisted semen analysis (CASA) performed using a Celltrack-S system.
Results:
Significant reductions in linearity (P < 0.05), amplitude of lateral head displacement (P < 0.01), straight line velocity (P < 0.01), and curvilinear velocity (P < 0.01) (but not percentage motility) were observed.
Conclusions:
Peritoneal fluid from women with minimal or mild endometriosis adversely effects sperm movement characteristics in comparison to fertile women.