Lack of arrhythmogenicity of aminophylline in dogs

This study was designed to determine if doses of aminophylline up to 10 mg/kg given i.v. would produce ventricular arrhythmias in seven healthy dogs anaesthetized with fentanyl-droperidol-pentobarbital. Arrhythmias were sought by inspection of ECGs before and after attempts at provoking them with 5 micrograms/kg boluses of epinephrine given i.v., or by programmed electrical stimulation. After cumulative doses of 10 mg aminophylline/kg body weight, producing an estimated plasma concentration of greater than 30 micrograms/ml, no ventricular ectopia other than escape depolarizations were observed. We were unable to document an arrhythmogenic effect of aminophylline when given rapidly by the i.v. route. It is possible that the anaesthetic regimen reduced the arrhythmogenic property of aminophylline, or that arrhythmias might be produced in either obese or ill dogs; but it is unlikely that chronic administration of aminophylline would be more arrhythmogenic.