Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Nitric oxide--more than a vasodilator]

M G Persson1, N P Wiklund, L E Gustafsson

  • 1Fysiologiska institutionen I, Karolinska institutet, Stockholm.

Lakartidningen
|April 7, 1993
PubMed
Summary

Nitric oxide (NO), synthesized from arginine, regulates blood pressure, neuronal activity, and immune defense. Its mechanism, though recently understood, is crucial for various bodily functions and is being explored in clinical trials.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tips and tricks for intracorporeal robot-assisted urinary diversion.

Current urology reports·2014
Same author

Robot-assisted radical cystectomy with intracorporeal neobladder diversion: The Karolinska experience.

Indian journal of urology : IJU : journal of the Urological Society of India·2014
Same author

Estimation of endogenous adenosine activity at adenosine receptors in guinea-pig ileum using a new pharmacological method.

Acta physiologica (Oxford, England)·2010
Same author

Robotic cystectomy.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2009
Same author

Localization and expression of inducible nitric oxide synthase in biopsies from patients with interstitial cystitis.

The Journal of urology·2008
Same author

Effects of nitric oxide synthase inhibition on blood flow and survival in experimental skin flaps.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2007

Area of Science:

  • Biochemistry
  • Physiology
  • Pharmacology

Context:

  • Nitric oxide (NO) is a critical signaling molecule synthesized from the amino acid arginine.
  • Endothelium-dependent vasodilation is a primary function mediated by NO.
  • NO plays diverse regulatory roles across multiple organ systems.

Purpose:

  • To elucidate the mechanism of action for nitric oxide (NO) in physiological processes.
  • To highlight the broad regulatory functions of NO in the body.
  • To introduce the recent understanding of NO's role and ongoing clinical investigations.

Summary:

  • Nitric oxide (NO) is synthesized from arginine and mediates endothelium-dependent vasodilation.
  • NO is vital for regulating blood pressure, neuronal activity (central and peripheral), lung ventilation-perfusion matching, and immune defense.
  • The mechanism of action of NO, particularly its liberation from compounds like nitroglycerin, has been recently elucidated.

Impact:

  • Understanding NO's synthesis and function is key to comprehending cardiovascular and neurological regulation.
  • The identification of endogenous NO synthesis inhibitors opens new avenues for therapeutic interventions.
  • Ongoing clinical trials examining NO and its inhibitors promise advancements in treating various conditions.

Related Experiment Videos