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Pharmacologic intervention in ischemia-induced reperfusion injury in the skeletal muscle
C Y Pang1, C R Forrest, R Mounsey
1Division of Surgical Research, Hospital for Sick Children, Toronto, Ontario, Canada.
Microsurgery
|January 1, 1993
Abstract:
This article provides a concise review on the potential causes of ischemia-induced reperfusion (I/R) injury and pharmacologic intervention in the skeletal muscle. Special emphasis is placed on the recent observation of the acute ischemic preconditioning phenomenon for prevention of I/R injury in skeletal muscle. Finally, the mechanism of ischemic preconditioning and its clinical applications for augmentation of skeletal muscle tolerance to prolonged ischemic insult are discussed.