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Antiinflammatory activity of aminoketone derivatives of 2,4-disubstituted thiazoles
D Hadjipavlou Litina1, A Geronikaki, E Sotiropoulou
1Department of Pharmaceutical Chemistry, School of Pharmacy, University of Thessaloniki, Greece.
Research Communications in Chemical Pathology and Pharmacology
|March 1, 1993
Abstract:
A group of nine aminoketones, 2,4-disubstituted thiazole derivatives were tested in vivo in order to evaluate their biological activity. Antiinflammatory activity was studied by means of the carrageenin-induced mouse paw edema. Writhing induced by acetic acid in rats used to evaluate the analgesic activity. The results are discussed from the view of structure activity relationship.