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Clinical experiences with trandolapril

C A Gaillard1, P W de Leeuw

  • 1Department of Medicine, University Hospital Maasstricht, The Netherlands.

American Heart Journal
|May 1, 1993
PubMed
Summary
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Trandolapril, a new angiotensin-converting enzyme inhibitor, effectively lowers blood pressure in hypertensive patients. Its long half-life and lipophilicity offer distinct clinical advantages.

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Hypertension remains a significant global health concern.
  • Angiotensin-converting enzyme (ACE) inhibitors are a cornerstone of antihypertensive therapy.

Purpose of the Study:

  • To review the clinical experiences with trandolapril, a novel non-sulfhydryl ACE inhibitor.
  • To evaluate the efficacy and characteristics of trandolapril in managing hypertension.

Main Methods:

  • Review of clinical data and experiences with trandolapril.
  • Analysis of pharmacokinetic properties including plasma half-life and lipophilicity.

Main Results:

  • Trandolapril demonstrates effective blood pressure reduction in patients with mild-to-severe hypertension.

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  • Efficacy was observed across diverse patient populations, including the elderly and obese.
  • The drug is characterized by a long plasma half-life and high lipophilicity.

    • Conclusions:

    • Trandolapril is an effective antihypertensive agent.
    • Its pharmacokinetic profile suggests potential for improved patient compliance and therapeutic outcomes.