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Vasa vasorum changes following stent placement in experimental arterial stenoses
J M Pisco1, M Correia, J A Esperança-Pina
1Department of Radiology, Sta Marta Hospital, Lisboa, Portugal.
Journal of Vascular and Interventional Radiology : JVIR
|March 1, 1993
Summary
Stent placement and balloon angioplasty temporarily increased vasa vasorum in canine aortae. Vessel proliferation peaked at 12 months, then regressed, indicating temporary effects of these interventions on blood vessels.
Area of Science:
- Vascular Biology
- Interventional Cardiology
- Animal Models
Background:
- The vasa vasorum (VV) are small blood vessels supplying the arterial wall.
- Understanding VV response to endovascular interventions is crucial for evaluating treatment efficacy and safety.
Purpose of the Study:
- To compare the effects of stent placement versus balloon angioplasty on the vasa vasorum in experimental canine aortic stenoses.
Main Methods:
- Experimental stenoses were created in canine aortae.
- Palmaz stents were placed in proximal stenoses, and balloon angioplasty in distal stenoses.
- Vessel changes were assessed using microangiography, histology, and electron microscopy at 4, 8, 12, and 18 months.
Main Results:
- Proliferation of vasa vasorum and formation of a rich plexus were observed up to 12 months post-intervention.
- Stent placement resulted in greater vasa vasorum proliferation compared to balloon angioplasty.
- New vessels, primarily venules in the media, regressed by 18 months, returning VV distribution to baseline.
Conclusions:
- Endovascular interventions, including stenting and angioplasty, induce temporary changes in the vasa vasorum.
- The observed proliferation and subsequent regression of vasa vasorum suggest a transient response to arterial injury and treatment.