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Related Experiment Videos

Does constitutional delayed puberty cause segmental disproportion and short stature?

A Albanese1, R Stanhope

  • 1Medical Unit, Institute of Child Health, London, UK.

European Journal of Pediatrics
|April 1, 1993
PubMed
Summary

Children with delayed growth and puberty often don't reach their predicted final height. Late puberty onset may negatively impact spinal growth and overall stature.

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Area of Science:

  • Pediatric Endocrinology
  • Growth and Development
  • Human Physiology

Background:

  • Constitutional delay of growth and puberty (CDGP) is a common condition in children.
  • Patients with CDGP typically experience a later onset of puberty and a prolonged growth period.
  • Understanding factors influencing final height attainment in CDGP is crucial for clinical management.

Purpose of the Study:

  • To evaluate final height attainment in children with constitutional delay of growth and puberty.
  • To compare achieved final height with predicted final height and mid-parental height.
  • To investigate potential factors contributing to discrepancies in final height, such as body segment proportions.

Main Methods:

  • Retrospective review of growth data for 98 boys and 34 girls with CDGP.

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  • Data collection included chronological age, pubertal status, height standard deviation scores (SDS), predicted final height SDS, mid-parental height SDS, sitting height SDS, and subischial leg length SDS.
  • Some patients received treatment with sex or anabolic steroids.

    • Main Results:

    • Boys with CDGP had a mean final height SDS of -1.9, significantly lower than predicted (-1.4) and mid-parental height (-0.5).
    • Girls with CDGP had a mean final height SDS of -2.3, significantly lower than predicted (-1.7) and mid-parental height (-0.8).
    • Both sexes presented with disproportionately short sitting height relative to leg length, a proportion that remained unchanged at final height.

    Conclusions:

    • Children with constitutional delay of growth and puberty may not achieve their predicted final height potential.
    • The study highlights a potential negative impact of late pubertal onset on spinal growth and final stature.
    • The underlying reasons for the failure to achieve optimal final height and the persistent disproportionate stature remain unexplained.