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Monoclonal anti-biotin antibodies simulate avidin in the recognition of biotin
H Bagçi1, F Kohen, U Kusçuoglu
1Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
FEBS Letters
|May 3, 1993
The sequence of the VH gene of a monoclonal anti-biotin antibody was determined. Biotin-binding motifs, similar to those in avidin and streptavidin, were identified in complementary determining regions 2 and 3, suggesting that natural selection of functional motifs may occur in unrelated protein types.
The sequence of the VH gene of a monoclonal anti-biotin antibody was determined. Biotin-binding motifs, similar to those in avidin and streptavidin, were identified in complementary determining regions 2 and 3, suggesting that natural selection of functional motifs may occur in unrelated protein types.