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An evaluation of two compact analyzers used for lipid analysis
J M McKenney1, D F Fary, G Miller
1School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
The Journal of Family Practice
|May 1, 1993
Summary
Compact analyzers offer convenient lipid testing, but triglyceride and LDL cholesterol measurements require improved accuracy. Physicians should carefully consider analyzer precision for accurate patient diagnosis and treatment decisions.
Area of Science:
- Clinical Chemistry
- Point-of-Care Testing
- Analytical Performance Evaluation
Background:
- Compact analyzers for total cholesterol, HDL cholesterol, and triglycerides are common in clinical settings.
- This study evaluates the analytical performance of Abbott Vision and Kodak Ektachem DT60 devices.
Purpose of the Study:
- To document the analytical performance of Abbott Vision and Kodak Ektachem DT60 analyzers.
- To assess accuracy, precision, and total error for lipid assays.
- To compare patient risk classification using device results versus a standardized laboratory.
Main Methods:
- Lipid profiles were measured from 70 subjects using both devices and compared to CDC-standardized laboratory results.
- Precision (CV), accuracy (bias), and total error were determined.
- Patient risk categorization based on lipid levels was evaluated.
Main Results:
- Both analyzers met performance guidelines for total and HDL cholesterol.
- Triglyceride and LDL cholesterol measurements showed significant inaccuracies and imprecision.
- Patient risk classification for total and LDL cholesterol was clinically acceptable with both devices.
Conclusions:
- Current compact analyzer technology requires improvement for accurate LDL cholesterol measurement.
- Clinicians must be aware of potential inaccuracies and imprecisions in compact analyzer lipid results for informed decision-making.