Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is cis-platinum vestibulotoxic?

S F Myers1, B W Blakley, S Schwan

  • 1Department of Otolaryngology, Wayne State University, Detroit, Michigan.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Substituent Pattern Effects on the Redox Potentials of Quinone-Based Active Materials for Aqueous Redox Flow Batteries.

ChemSusChem·2020
Same author

Calcium Microcrystal Formation in Recurrent Herniation Patients After Autologous Disc Cell Transplantation.

Tissue engineering and regenerative medicine·2019
Same author

Comparison of palmar fixed-angle plate fixation with K-wire fixation of distal radius fractures (AO A2, A3, C1) in elderly patients.

The Journal of hand surgery, European volume·2013
Same author

Microporous calcium phosphate ceramics as tissue engineering scaffolds for the repair of osteochondral defects: biomechanical results.

Acta biomaterialia·2012
Same author

Hearing loss in the elderly: an overview.

Canadian family physician Medecin de famille canadien·2011
Same author

A novel MSC-seeded triphasic construct for the repair of osteochondral defects.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2010

This study found no significant vestibular toxicity in patients receiving high-dose cis-platinum chemotherapy, even with cumulative dosages up to 1600 mg. Vestibular testing showed no clear evidence of damage in chemotherapy patients compared to normal subjects.

Area of Science:

  • Neuroscience
  • Oncology
  • Ototoxicology

Background:

  • Cis-platinum chemotherapy is a vital cancer treatment.
  • Vestibular dysfunction is a potential side effect of chemotherapy.
  • Early detection of subclinical vestibular toxicity is crucial for patient management.

Purpose of the Study:

  • To assess vestibular function in patients undergoing cis-platinum chemotherapy.
  • To evaluate for subclinical vestibular toxicity.
  • To establish normative data for vestibular testing in a control group.

Main Methods:

  • Serial vestibular testing including caloric and low-frequency sinusoidal rotational tests.
  • Comparison of test results between 34 cis-platinum chemotherapy patients and 12 age-matched normal subjects.

Related Experiment Videos

  • Analysis of test-retest variability in normal subjects to define subclinical dysfunction thresholds.

    • Main Results:

    • No clear evidence of vestibular toxicity was detected in patients receiving high-dose cis-platinum chemotherapy (100 mg/m2).
    • Cumulative dosages up to 1600 mg did not correlate with significant vestibular impairment.
    • Vestibular function in chemotherapy patients was comparable to age-matched controls.

    Conclusions:

    • High-dose cis-platinum chemotherapy, as administered in this study, does not appear to cause significant vestibular toxicity.
    • Current vestibular testing methods may not detect very early or subclinical changes.
    • Further research may be needed to refine detection of chemotherapy-induced vestibular damage.